Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension

OBJECTIVE: Pulmonary arterial hypertension (PAH) is a debilitating disease associated with progressive vascular remodeling of distal pulmonary arteries leading to elevation of pulmonary artery pressure, right ventricular hypertrophy, and death. Although presenting high levels of DNA damage that norm...

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Publié dans:Arterioscler Thromb Vasc Biol
Auteurs principaux: Bourgeois, Alice, Bonnet, Sébastien, Breuils-Bonnet, Sandra, Habbout, Karima, Paradis, Renée, Tremblay, Eve, Lampron, Marie-Claude, Orcholski, Mark E., Potus, Francois, Bertero, Thomas, Peterlini, Thibaut, Chan, Stephen Y., Norris., Karen A, Paulin, Roxane, Provencher, Steeve, Boucherat, Olivier
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727643/
https://ncbi.nlm.nih.gov/pubmed/31092016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.312537
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