Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension

OBJECTIVE: Pulmonary arterial hypertension (PAH) is a debilitating disease associated with progressive vascular remodeling of distal pulmonary arteries leading to elevation of pulmonary artery pressure, right ventricular hypertrophy, and death. Although presenting high levels of DNA damage that norm...

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Gepubliceerd in:Arterioscler Thromb Vasc Biol
Hoofdauteurs: Bourgeois, Alice, Bonnet, Sébastien, Breuils-Bonnet, Sandra, Habbout, Karima, Paradis, Renée, Tremblay, Eve, Lampron, Marie-Claude, Orcholski, Mark E., Potus, Francois, Bertero, Thomas, Peterlini, Thibaut, Chan, Stephen Y., Norris., Karen A, Paulin, Roxane, Provencher, Steeve, Boucherat, Olivier
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727643/
https://ncbi.nlm.nih.gov/pubmed/31092016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.312537
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