Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension

OBJECTIVE: Pulmonary arterial hypertension (PAH) is a debilitating disease associated with progressive vascular remodeling of distal pulmonary arteries leading to elevation of pulmonary artery pressure, right ventricular hypertrophy, and death. Although presenting high levels of DNA damage that norm...

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Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Bourgeois, Alice, Bonnet, Sébastien, Breuils-Bonnet, Sandra, Habbout, Karima, Paradis, Renée, Tremblay, Eve, Lampron, Marie-Claude, Orcholski, Mark E., Potus, Francois, Bertero, Thomas, Peterlini, Thibaut, Chan, Stephen Y., Norris., Karen A, Paulin, Roxane, Provencher, Steeve, Boucherat, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727643/
https://ncbi.nlm.nih.gov/pubmed/31092016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.312537
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