Synthesis and preliminary evaluation of [(11)C]GNE-1023 as a novel potent PET probe for imaging leucine-rich repeat kinase 2 (LRRK2) in Parkinson’s disease

Leucin-rich repeat kinase 2 (LRRK2) is a large protein that is involved in the pathogenesis of Parkinson’s disease (PD). It has been demonstrated that LRRK2 mutations mainly confers PD, which bring about increased kinase activity of LRRK2. As a consequence, selective inhibition of LRRK2 may help to...

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Bibliografske podrobnosti
izdano v:ChemMedChem
Main Authors: Chen, Zhen, Shao, Tuo, Gao, Wei, Fu, Hualong, Collier, Thomas Lee, Rong, Jian, Deng, Xiaoyun, Yu, Qingzhen, Zhang, Xiaofei, Davenport, April T., Daunais, James B., Wey, Hsiao-Ying, Shao, Yihan, Josephson, Lee, Qiu, Wen-Wei, Liang, Steven
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726558/
https://ncbi.nlm.nih.gov/pubmed/31365783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900321
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