Synthesis and preliminary evaluation of [(11)C]GNE-1023 as a novel potent PET probe for imaging leucine-rich repeat kinase 2 (LRRK2) in Parkinson’s disease

Leucin-rich repeat kinase 2 (LRRK2) is a large protein that is involved in the pathogenesis of Parkinson’s disease (PD). It has been demonstrated that LRRK2 mutations mainly confers PD, which bring about increased kinase activity of LRRK2. As a consequence, selective inhibition of LRRK2 may help to...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Chen, Zhen, Shao, Tuo, Gao, Wei, Fu, Hualong, Collier, Thomas Lee, Rong, Jian, Deng, Xiaoyun, Yu, Qingzhen, Zhang, Xiaofei, Davenport, April T., Daunais, James B., Wey, Hsiao-Ying, Shao, Yihan, Josephson, Lee, Qiu, Wen-Wei, Liang, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726558/
https://ncbi.nlm.nih.gov/pubmed/31365783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900321
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