Synthesis and preliminary evaluation of [(11)C]GNE-1023 as a novel potent PET probe for imaging leucine-rich repeat kinase 2 (LRRK2) in Parkinson’s disease

Leucin-rich repeat kinase 2 (LRRK2) is a large protein that is involved in the pathogenesis of Parkinson’s disease (PD). It has been demonstrated that LRRK2 mutations mainly confers PD, which bring about increased kinase activity of LRRK2. As a consequence, selective inhibition of LRRK2 may help to...

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Detaylı Bibliyografya
Yayımlandı:ChemMedChem
Asıl Yazarlar: Chen, Zhen, Shao, Tuo, Gao, Wei, Fu, Hualong, Collier, Thomas Lee, Rong, Jian, Deng, Xiaoyun, Yu, Qingzhen, Zhang, Xiaofei, Davenport, April T., Daunais, James B., Wey, Hsiao-Ying, Shao, Yihan, Josephson, Lee, Qiu, Wen-Wei, Liang, Steven
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726558/
https://ncbi.nlm.nih.gov/pubmed/31365783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900321
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