Synthesis and pharmacokinetic study of a (11)C-labeled cholesterol 24-hydroxylase inhibitor using ‘in-loop’ [(11)C]CO(2) fixation method

Cholesterol 24-hydroxylase, also known as CYP46A1 (EC 1.14.13.98), is a monooxygenase Received and a member of the cytochrome P450 family. CYP46A1 is specifically expressed in the brain Received in revised form where it controls cholesterol elimination by producing 24S-hydroxylcholesterol (24-HC) as...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Chen, Zhen, Chen, Jiahui, Mast, Natalia, Rong, Jian, Deng, Xiaoyun, Shao, Tuo, Fu, Hualong, Yu, Qingzhen, Sun, Jiyun, Shao, Yihan, Josephson, Lee, Collier, Thomas Lee, Pikuleva, Irina, Liang, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196435/
https://ncbi.nlm.nih.gov/pubmed/32178974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127068
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