APE1 upregulates MMP-14 via redox-sensitive ARF6-mediated recycling to promote cell invasion of esophageal adenocarcinoma

Esophageal adenocarcinoma (EAC) is an aggressive malignancy with poor clinical outcome. The incidence of EAC has been rising rapidly in the past three decades. Here, we showed that apurinic/apyrimidinic endonuclease (APE1) is overexpressed in EAC cell lines, and patients' samples of dysplasia a...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Lu, Heng, Bhat, Ajaz A., Peng, Dunfa, Chen, Zheng, Zhu, Shoumin, Hong, Jun, Maacha, Selma, Yan, Jin, Robbins, David J., Washington, M. Kay, Belkhiri, Abbes, El-Rifai, Wael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726537/
https://ncbi.nlm.nih.gov/pubmed/31308045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0237
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