APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts

Chronic Gastroesophageal Reflux Disease (GERD) is the main risk factor for the development of Barrett's esophagus (BE) and its progression to esophageal adenocarcinoma (EAC). Accordingly, EAC cells are subjected to high levels of oxidative stress and subsequent DNA damage. In this study, we inv...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Hong, Jun, Chen, Zheng, Peng, Dunfa, Zaika, Alexander, Revetta, Frank, Washington, M. Kay, Belkhiri, Abbes, El-Rifai, Wael
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941344/
https://ncbi.nlm.nih.gov/pubmed/26934647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7696
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