Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage

BACKGROUND: The incidence of esophageal adenocarcinoma (EAC) is rising rapidly in the US and Western countries. The development of Barrett’s esophagus (BE) and its progression to EAC have been linked to chronic gastroesophageal reflux disease (GERD). Exposure of BE and EAC cells to acidic bile salts...

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Bibliographic Details
Published in:J Exp Clin Cancer Res
Main Authors: Zhou, Zhangjian, Lu, Heng, Zhu, Shoumin, Gomaa, Ahmed, Chen, Zheng, Yan, Jin, Washington, Kay, El-Rifai, Wael, Dang, Chengxue, Peng, Dunfa
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327430/
https://ncbi.nlm.nih.gov/pubmed/30626422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-1021-y
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