Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage

BACKGROUND: The incidence of esophageal adenocarcinoma (EAC) is rising rapidly in the US and Western countries. The development of Barrett’s esophagus (BE) and its progression to EAC have been linked to chronic gastroesophageal reflux disease (GERD). Exposure of BE and EAC cells to acidic bile salts...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Zhou, Zhangjian, Lu, Heng, Zhu, Shoumin, Gomaa, Ahmed, Chen, Zheng, Yan, Jin, Washington, Kay, El-Rifai, Wael, Dang, Chengxue, Peng, Dunfa
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327430/
https://ncbi.nlm.nih.gov/pubmed/30626422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-1021-y
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