Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage

BACKGROUND: The incidence of esophageal adenocarcinoma (EAC) is rising rapidly in the US and Western countries. The development of Barrett’s esophagus (BE) and its progression to EAC have been linked to chronic gastroesophageal reflux disease (GERD). Exposure of BE and EAC cells to acidic bile salts...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Exp Clin Cancer Res
Päätekijät: Zhou, Zhangjian, Lu, Heng, Zhu, Shoumin, Gomaa, Ahmed, Chen, Zheng, Yan, Jin, Washington, Kay, El-Rifai, Wael, Dang, Chengxue, Peng, Dunfa
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2019
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327430/
https://ncbi.nlm.nih.gov/pubmed/30626422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-1021-y
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