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NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells

Gastroesophageal reflux disease (GERD) is the main risk factor for Barrett’s tumorigenesis. In this study, we investigated the role of NRF2 in response to exposure acidic bile salts (ABS), in conditions that mimic GERD, using Barrett’s esophagus cell models. We detected an increase in NRF2 protein l...

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Bibliografische gegevens
Gepubliceerd in:Cancer Lett
Hoofdauteurs: Peng, Dunfa, Lu, Heng, Zhu, Shoumin, Zhou, Zhangjian, Hu, Tianling, Chen, Zheng, Zaika, Alexander, El-Rifai, Wael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571054/
https://ncbi.nlm.nih.gov/pubmed/31132430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.05.031
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