Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells

BACKGROUND: Chronic gastroesophageal reflux disease (GERD) is a major risk factor for the development of metaplastic Barrett's esophagus (BE) and its progression to esophageal adenocarcinoma (EAC). Uncontrolled accumulation of reactive oxygen species (ROS) in response to acidic bile salts (ABS)...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Sriramajayam, Kannappan, Peng, Dunfa, Lu, Heng, Zhou, Shoumin, Bhat, Nadeem, McDonald, Oliver G., Que, Jianwen, Zaika, Alexander, El-Rifai, Wael
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082268/
https://ncbi.nlm.nih.gov/pubmed/33887608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.101970
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