Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells

BACKGROUND: Chronic gastroesophageal reflux disease (GERD) is a major risk factor for the development of metaplastic Barrett's esophagus (BE) and its progression to esophageal adenocarcinoma (EAC). Uncontrolled accumulation of reactive oxygen species (ROS) in response to acidic bile salts (ABS)...

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Dades bibliogràfiques
Publicat a:Redox Biol
Autors principals: Sriramajayam, Kannappan, Peng, Dunfa, Lu, Heng, Zhou, Shoumin, Bhat, Nadeem, McDonald, Oliver G., Que, Jianwen, Zaika, Alexander, El-Rifai, Wael
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082268/
https://ncbi.nlm.nih.gov/pubmed/33887608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.101970
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