Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells

BACKGROUND: Chronic gastroesophageal reflux disease (GERD) is a major risk factor for the development of metaplastic Barrett's esophagus (BE) and its progression to esophageal adenocarcinoma (EAC). Uncontrolled accumulation of reactive oxygen species (ROS) in response to acidic bile salts (ABS)...

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Veröffentlicht in:Redox Biol
Hauptverfasser: Sriramajayam, Kannappan, Peng, Dunfa, Lu, Heng, Zhou, Shoumin, Bhat, Nadeem, McDonald, Oliver G., Que, Jianwen, Zaika, Alexander, El-Rifai, Wael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082268/
https://ncbi.nlm.nih.gov/pubmed/33887608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.101970
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