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DARPP-32 Increases Interactions Between Epidermal Growth Factor Receptor and ERBB3 to Promote Tumor Resistance to Gefitinib

BACKGROUND & AIMS: Dopamine and cAMP-regulated phosphoprotein, Mr 32000 (DARPP-32), is overexpressed during gastric carcinogenesis. Gastric tumors can become resistant to gefitinib, an inhibitor of the epidermal growth factor receptor (EGFR). We investigated the role of DARPP-32 in gastric tumor...

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Detalhes bibliográficos
Main Authors: Zhu, Shoumin, Belkhiri, Abbes, El-Rifai, Wael
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202055/
https://ncbi.nlm.nih.gov/pubmed/21741919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.06.070
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