Toll-Like Receptor 4 on Nonhematopoietic Cells Sustains CNS Inflammation during Endotoxemia, Independent of Systemic Cytokines

Inflammatory agonists such as lipopolysaccharide (LPS) induce robust systemic as well as CNS responses after peripheral administration. Responses in the innate immune system require triggering of toll-like receptor 4 (TLR4), but the origin of CNS sequelas has been controversial. We demonstrate expre...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Chakravarty, Sumana, Herkenham, Miles
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2005
Subjects:
Neurobiology of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725921/
https://ncbi.nlm.nih.gov/pubmed/15716415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4268-04.2005
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