Endothelial Nox2 Limits Systemic Inflammation and Hypotension in Endotoxemia by Controlling Expression of Toll-Like Receptor 4

Leukocyte Nox2 is recognized to have a fundamental microbicidal function in sepsis but the specific role of Nox2 in endothelial cells (EC) remains poorly elucidated. Here, we tested the hypothesis that endothelial Nox2 participates in the pathogenesis of systemic inflammation and hypotension induced...

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Detalhes bibliográficos
Publicado no:Shock
Main Authors: Trevelin, Silvia Cellone, Sag, Can Martin, Zhang, Min, Alves-Filho, José Carlos, Cunha, Thiago Mattar, dos Santos, Célio Xavier, Sawyer, Greta, Murray, Thomas, Brewer, Alison, Laurindo, Francisco Rafael Martins, Protti, Andrea, Lopes, Lucia Rossetti, Ivetic, Aleksandar, Cunha, Fernando Queiroz, Shah, Ajay M.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2021
Assuntos:
Basic Science Aspects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284354/
https://ncbi.nlm.nih.gov/pubmed/34276040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000001706
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