Downregulation of Cytosolic Prostaglandin E(2) Synthase Results in Decreased Nociceptive Behavior in Rats

Nociception-evoked prostaglandin E(2) (PGE(2)) release in the spinal cord contributes considerably to the development of hyperalgesia and allodynia. Biosynthesis of PGE(2) involves the conversion of arachidonic acid to PGH(2) by cyclooxygenases (COXs), followed by an isomerization of PGH(2) to PGE(2...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Hofacker, Annette, Coste, Ovidiu, Nguyen, Hong-Van, Marian, Claudiu, Scholich, Klaus, Geisslinger, Gerd
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725604/
https://ncbi.nlm.nih.gov/pubmed/16192391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2190-05.2005
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