Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice

Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E(2) synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE(2) synthase-1 (mPGES-1) isomerizes COX-2-derived PGH(2) to PGE(2). Here, we evaluated the effect of mPGES-1-deficie...

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Detalhes bibliográficos
Main Authors: Brenneis, Christian, Coste, Ovidiu, Schmidt, Ronald, Angioni, Carlo, Popp, Laura, Nusing, Rolf M, Becker, Wiebke, Scholich, Klaus, Geisslinger, Gerd
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2008
Assuntos:
Images in Cellular / Molecular Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822549/
https://ncbi.nlm.nih.gov/pubmed/18419601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2007.00110.x
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