Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation

BACKGROUND: Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers. Three of the EETs (i.e., 8,9-, 11,12- and 14,15-EET) are rapidly hydrolysed by the enzyme soluble epoxide hydrolase (sEH). Here, we...

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Hlavní autoři: Brenneis, Christian, Sisignano, Marco, Coste, Ovidiu, Altenrath, Kai, Fischer, Michael J, Angioni, Carlo, Fleming, Ingrid, Brandes, Ralf P, Reeh, Peter W, Woolf, Clifford J, Geisslinger, Gerd, Scholich, Klaus
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195722/
https://ncbi.nlm.nih.gov/pubmed/21970373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-78
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