Soluble epoxide hydrolase deficiency attenuates neo-intima formation in the femoral cuff model of hyperlipidemic mice

OBJECTIVES: Epoxyeicosatrienoic acids (EETs) have anti-inflammatory effects and are required for normal endothelial function. The soluble epoxide hydrolase (sEH) metabolizes EETs to their less active diols. We hypothesized that knockout and inhibition of sEH prevents neo-intima formation in hyperlip...

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Main Authors: Revermann, Marc, Schloss, Manuel, Barbosa-Sicard, Eduardo, Mieth, Anja, Liebner, Stefan, Morisseau, Christophe, Geisslinger, Gerd, Schermuly, Ralph T., Fleming, Ingrid, Hammock, Bruce D., Brandes, Ralf P.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919323/
https://ncbi.nlm.nih.gov/pubmed/20224052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.204099
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