Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase deletion vs. inhibition

AIMS: The C-terminal domain of the soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity. As EETs are potent vasoconstrictors in the pulmonary circulation, we assessed the developme...

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Autors principals: Keserü, Benjamin, Barbosa-Sicard, Eduardo, Schermuly, Ralph T., Tanaka, Hiromasa, Hammock, Bruce D., Weissmann, Norbert, Fisslthaler, Beate, Fleming, Ingrid
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860707/
https://ncbi.nlm.nih.gov/pubmed/19679679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvp281
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