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Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response

Recent findings have indicated a role for cytochrome P-450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) in acute hypoxic pulmonary vasoconstriction (HPV). Given that the intracellular concentration of EETs is determined by the soluble epoxide hydrolase (sEH), we assessed the influence...

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Detalhes bibliográficos
Main Authors: Keserü, Benjamin, Barbosa-Sicard, Eduardo, Popp, Rüdiger, Fisslthaler, Beate, Dietrich, Alexander, Gudermann, Thomas, Hammock, Bruce D., Falck, John R., Weissmann, Norbert, Busse, Rudi, Fleming, Ingrid
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614611/
https://ncbi.nlm.nih.gov/pubmed/18725458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-112821
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