Cytochrome P450 Epoxygenase Gene Function in Hypoxic Pulmonary Vasoconstriction and Pulmonary Vascular Remodeling

We assessed pulmonary cytochrome P450 (CYP) epoxygenase expression and activity during hypoxia and explored the effects of modulating epoxygenase activity on pulmonary hypertension. The acute hypoxic vasoconstrictor response was studied in Swiss Webster mice, who express CYP2C29 in their lungs. Anim...

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Hlavní autoři: Pokreisz, Peter, Fleming, Ingrid, Kiss, Ladislau, Barbosa-Sicard, Eduardo, Fisslthaler, Beate, Falck, John R., Hammock, Bruce D., Kim, In-Hae, Szelid, Zsolt, Vermeersch, Pieter, Gillijns, Hilde, Pellens, Marijke, Grimminger, Friedrich, van Zonneveld, Anton-Jan, Collen, Desire, Busse, Rudi, Janssens, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1993904/
https://ncbi.nlm.nih.gov/pubmed/16505204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.HYP.0000208299.62535.58
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