Cytochrome P450 Epoxygenase Gene Function in Hypoxic Pulmonary Vasoconstriction and Pulmonary Vascular Remodeling

We assessed pulmonary cytochrome P450 (CYP) epoxygenase expression and activity during hypoxia and explored the effects of modulating epoxygenase activity on pulmonary hypertension. The acute hypoxic vasoconstrictor response was studied in Swiss Webster mice, who express CYP2C29 in their lungs. Anim...

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Autori principali: Pokreisz, Peter, Fleming, Ingrid, Kiss, Ladislau, Barbosa-Sicard, Eduardo, Fisslthaler, Beate, Falck, John R., Hammock, Bruce D., Kim, In-Hae, Szelid, Zsolt, Vermeersch, Pieter, Gillijns, Hilde, Pellens, Marijke, Grimminger, Friedrich, van Zonneveld, Anton-Jan, Collen, Desire, Busse, Rudi, Janssens, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1993904/
https://ncbi.nlm.nih.gov/pubmed/16505204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.HYP.0000208299.62535.58
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