Inhibition of the Soluble Epoxide Hydrolase Promotes Albuminuria in Mice with Progressive Renal Disease

Epoxyeicotrienoic acids (EETs) are cytochrome P450-dependent anti-hypertensive and anti-inflammatory derivatives of arachidonic acid, which are highly abundant in the kidney and considered reno-protective. EETs are degraded by the enzyme soluble epoxide hydrolase (sEH) and sEH inhibitors are conside...

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Autors principals: Jung, Oliver, Jansen, Felix, Mieth, Anja, Barbosa-Sicard, Eduardo, Pliquett, Rainer U., Babelova, Andrea, Morisseau, Christophe, Hwang, Sung H., Tsai, Cindy, Hammock, Bruce D., Schaefer, Liliana, Geisslinger, Gerd, Amann, Kerstin, Brandes, Ralf P.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915917/
https://ncbi.nlm.nih.gov/pubmed/20694143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011979
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