Acute γ-Secretase Inhibition Improves Contextual Fear Conditioning in the Tg2576 Mouse Model of Alzheimer's Disease

Transgenic mice (Tg2576) overexpressing the Swedish mutation of the human amyloid precursor protein display biochemical, pathological, and behavioral markers consistent with many aspects of Alzheimer's disease, including impaired hippocampal function. Impaired, hippocampal-dependent, contextual...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Comery, Thomas A., Martone, Robert L., Aschmies, Suzan, Atchison, Kevin P., Diamantidis, George, Gong, Xiaohai, Zhou, Hua, Kreft, Anthony F., Pangalos, Menelas N., Sonnenberg-Reines, June, Jacobsen, J. Steven, Marquis, Karen L.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2005
Assuntos:
Brief Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725598/
https://ncbi.nlm.nih.gov/pubmed/16192379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2693-05.2005
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