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Antisense Inhibition at the β-Secretase-Site of APP Reduces Cerebral Amyloid and AChE Activity in Tg2576
Misprocessing of β-amyloid precursor protein (APP) leading to the formation of elevated quantities of β-amyloid peptide (Aβ), derived by a cleavage at the β-secretase site (N-671/673aa) and by a cleavage at the γ-secretase site (C-711/713aa) of APP, is considered a key event in the pathogenesis of A...
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Main Authors: | , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2007
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1955231/ https://ncbi.nlm.nih.gov/pubmed/17303345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2007.01.008 |
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