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Antisense Inhibition at the β-Secretase-Site of APP Reduces Cerebral Amyloid and AChE Activity in Tg2576

Misprocessing of β-amyloid precursor protein (APP) leading to the formation of elevated quantities of β-amyloid peptide (Aβ), derived by a cleavage at the β-secretase site (N-671/673aa) and by a cleavage at the γ-secretase site (C-711/713aa) of APP, is considered a key event in the pathogenesis of A...

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Bibliografski detalji
Glavni autori: Chauhan, Neelima B., Siegel, George J.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955231/
https://ncbi.nlm.nih.gov/pubmed/17303345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2007.01.008
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