Intracerebroventricular amyloid-β antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice

Although immunization against amyloid-β (Aβ) holds promise as a disease-modifying therapy for Alzheimer disease (AD), it is associated with an undesirable accumulation of amyloid in the cerebrovasculature [i.e., cerebral amyloid angiopathy (CAA)] and a heightened risk of micro-hemorrhages. The centr...

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Detalhes bibliográficos
Main Authors: Thakker, Deepak R., Weatherspoon, Marcy R., Harrison, Jonathan, Keene, Thomas E., Lane, Deanna S., Kaemmerer, William F., Stewart, Gregory R., Shafer, Lisa L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647980/
https://ncbi.nlm.nih.gov/pubmed/19246392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813404106
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