Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice

Multiple small-molecule inhibitors of the β-secretase enzyme (BACE1) are under preclinical or clinical investigation for Alzheimer's disease (AD). Prior work has illustrated robust lowering of central amyloid β (Aβ) after acute administration of BACE1 inhibitors. However, very few studies have...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Thakker, Deepak R., Sankaranarayanan, Sethu, Weatherspoon, Marcy R., Harrison, Jonathan, Pierdomenico, Maria, Heisel, Jennifer M., Thompson, Lorin A., Haskell, Roy, Grace, James E., Taylor, Sarah J., Albright, Charles F., Shafer, Lisa L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605183/
https://ncbi.nlm.nih.gov/pubmed/25926467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2262-14.2015
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