AZ-4217: A High Potency BACE Inhibitor Displaying Acute Central Efficacy in Different In Vivo Models and Reduced Amyloid Deposition in Tg2576 Mice

Aβ, the product of APP (amyloid precursor protein), has been implicated in the pathophysiology of Alzheimer's disease (AD). β-Site APP cleaving enzyme1 (BACE1) is the enzyme initiating the processing of the APP to Aβ peptides. Small molecule BACE1 inhibitors are expected to decrease Aβ-peptide...

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Udgivet i:J Neurosci
Main Authors: Eketjäll, Susanna, Janson, Juliette, Jeppsson, Fredrik, Svanhagen, Alexander, Kolmodin, Karin, Gustavsson, Susanne, Radesäter, Ann-Cathrin, Eliason, Kristina, Briem, Sveinn, Appelkvist, Paulina, Niva, Camilla, Berg, Anna-Lena, Karlström, Sofia, Swahn, Britt-Marie, Fälting, Johanna
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618391/
https://ncbi.nlm.nih.gov/pubmed/23761903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1165-13.2013
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