Impact of chemical modification of sulfamidase on distribution to brain interstitial fluid and to CSF after an intravenous administration in awake, freely-moving rats

por Janson, Juliette, Andersson, Gudrun, Bergquist, Lars, Eriksson, Maria, Folgering, Joost H.A.
Publicado no Mol Genet Metab Rep (2019)

AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics

por Eketjäll, Susanna, Janson, Juliette, Kaspersson, Karin, Bogstedt, Anna, Jeppsson, Fredrik, Fälting, Johanna, Haeberlein, Samantha Budd, Kugler, Alan R., Alexander, Robert C., Cebers, Gvido
Publicado no J Alzheimers Dis (2016)

Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic β cells through activation of phosphatidylinositol 4-kinase β

por Gromada, Jesper, Bark, Christina, Smidt, Kamille, Efanov, Alexander M., Janson, Juliette, Mandic, Slavena A., Webb, Dominic-Luc, Zhang, Wei, Meister, Björn, Jeromin, Andreas, Berggren, Per-Olof
Publicado em 2005

Intravenous delivery of a chemically modified sulfamidase efficiently reduces heparan sulfate storage and brain pathology in mucopolysaccharidosis IIIA mice

por Gustavsson, Susanne, Ohlin Sjöström, Elisabet, Tjernberg, Agneta, Janson, Juliette, Westermark, Ulrica, Andersson, Tommy, Makower, Åsa, Arnelöf, Erik, Andersson, Gudrun, Svartengren, Jan, Ekholm, Carina, Svensson Gelius, Stefan
Publicado no Mol Genet Metab Rep (2019)

An Ancient Duplication of Exon 5 in the Snap25 Gene Is Required for Complex Neuronal Development/Function

por Johansson, Jenny U., Ericsson, Jesper, Janson, Juliette, Beraki, Simret, Stanić, Davor, Mandic, Slavena A., Wikström, Martin A., Hökfelt, Tomas, Ögren, Sven Ove, Rozell, Björn, Berggren, Per-Olof, Bark, Christina
Publicado em 2008

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

por Jeppsson, Fredrik, Eketjäll, Susanna, Janson, Juliette, Karlström, Sofia, Gustavsson, Susanne, Olsson, Lise-Lotte, Radesäter, Ann-Cathrine, Ploeger, Bart, Cebers, Gvido, Kolmodin, Karin, Swahn, Britt-Marie, von Berg, Stefan, Bueters, Tjerk, Fälting, Johanna
Publicado em 2012

AZ-4217: A High Potency BACE Inhibitor Displaying Acute Central Efficacy in Different In Vivo Models and Reduced Amyloid Deposition in Tg2576 Mice

por Eketjäll, Susanna, Janson, Juliette, Jeppsson, Fredrik, Svanhagen, Alexander, Kolmodin, Karin, Gustavsson, Susanne, Radesäter, Ann-Cathrin, Eliason, Kristina, Briem, Sveinn, Appelkvist, Paulina, Niva, Camilla, Berg, Anna-Lena, Karlström, Sofia, Swahn, Britt-Marie, Fälting, Johanna
Publicado no J Neurosci (2013)

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β

por Henderson, Simon J., Andersson, Christin, Narwal, Rajesh, Janson, Juliette, Goldschmidt, Tom J., Appelkvist, Paulina, Bogstedt, Anna, Steffen, Ann-Charlott, Haupts, Ulrich, Tebbe, Jan, Freskgård, Per Ola, Jermutus, Lutz, Burrell, Matthew, Fowler, Susan B., Webster, Carl I.
Publicado em 2014