An Ancient Duplication of Exon 5 in the Snap25 Gene Is Required for Complex Neuronal Development/Function

Alternative splicing is an evolutionary innovation to create functionally diverse proteins from a limited number of genes. SNAP-25 plays a central role in neuroexocytosis by bridging synaptic vesicles to the plasma membrane during regulated exocytosis. The SNAP-25 polypeptide is encoded by a single...

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Main Authors: Johansson, Jenny U., Ericsson, Jesper, Janson, Juliette, Beraki, Simret, Stanić, Davor, Mandic, Slavena A., Wikström, Martin A., Hökfelt, Tomas, Ögren, Sven Ove, Rozell, Björn, Berggren, Per-Olof, Bark, Christina
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581893/
https://ncbi.nlm.nih.gov/pubmed/19043548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000278
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