Targeting Amyloid-β Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-β Production

Alterations in amyloid beta precursor protein (APP) have been implicated in cognitive decline in Alzheimer’s disease (AD), which is accelerated in Down syndrome/Trisomy 21 (DS/TS21), likely due to the extra copy of the APP gene, located on chromosome 21. Proteolytic cleavage of APP generates amyloid...

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Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: Chang, Jennifer L., Hinrich, Anthony J., Roman, Brandon, Norrbom, Michaela, Rigo, Frank, Marr, Robert A., Norstrom, Eric M., Hastings, Michelle L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2018
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986716/
https://ncbi.nlm.nih.gov/pubmed/29628304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.02.029
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