Promiscuity of the catalytic Sec7 domain within the guanine nucleotide exchange factor GBF1 in ARF activation, Golgi homeostasis, and effector recruitment

The integrity of the Golgi and trans-Golgi network (TGN) is disrupted by brefeldin A (BFA), which inhibits the Golgi-localized BFA-sensitive factor (GBF1) and brefeldin A–inhibited guanine nucleotide-exchange factors (BIG1 and BIG2). Using a cellular replacement assay to assess GBF1 functionality wi...

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Foilsithe in:Mol Biol Cell
Main Authors: Bhatt, Jay M., Hancock, William, Meissner, Justyna M., Kaczmarczyk, Aneta, Lee, Eunjoo, Viktorova, Ekaterina, Ramanadham, Sasanka, Belov, George A., Sztul, Elizabeth
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Cell Biology 2019
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724685/
https://ncbi.nlm.nih.gov/pubmed/30943106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-11-0711
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