Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation

Lipoic acid (LA) is a redox-active disulphide compound, which functions as a pivotal co-factor for mitochondrial oxidative decarboxylation. LA and chemical derivatives were shown to target mitochondria in cancer cells with altered energy metabolism, thereby inducing cell death. In this study, the im...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cells
Hauptverfasser: Neitzel, Carina, Seiwert, Nina, Göder, Anja, Diehl, Erika, Weber, Carina, Nagel, Georg, Stroh, Svenja, Rasenberger, Birgit, Christmann, Markus, Fahrer, Jörg
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721634/
https://ncbi.nlm.nih.gov/pubmed/31366086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8080794
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge