AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells

DNA double-strand breaks (DSBs) are critical DNA lesions, which threaten genome stability and cell survival. DSBs are directly induced by ionizing radiation (IR) and radiomimetic agents, including the cytolethal distending toxin (CDT). This bacterial genotoxin harbors a unique DNase-I-like endonucle...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Seiwert, Nina, Neitzel, Carina, Stroh, Svenja, Frisan, Teresa, Audebert, Marc, Toulany, Mahmoud, Kaina, Bernd, Fahrer, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596597/
https://ncbi.nlm.nih.gov/pubmed/28837154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.418
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