AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells

DNA double-strand breaks (DSBs) are critical DNA lesions, which threaten genome stability and cell survival. DSBs are directly induced by ionizing radiation (IR) and radiomimetic agents, including the cytolethal distending toxin (CDT). This bacterial genotoxin harbors a unique DNase-I-like endonucle...

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Publicat a:Cell Death Dis
Autors principals: Seiwert, Nina, Neitzel, Carina, Stroh, Svenja, Frisan, Teresa, Audebert, Marc, Toulany, Mahmoud, Kaina, Bernd, Fahrer, Jörg
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596597/
https://ncbi.nlm.nih.gov/pubmed/28837154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.418
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