DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP

PhIP is an abundant heterocyclic aromatic amine (HCA) and important dietary carcinogen. Following metabolic activation, PhIP causes bulky DNA lesions at the C8-position of guanine. Although C8-PhIP-dG adducts are mutagenic, their interference with the DNA replication machinery and the elicited DNA d...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Mimmler, Maximilian, Peter, Simon, Kraus, Alexander, Stroh, Svenja, Nikolova, Teodora, Seiwert, Nina, Hasselwander, Solveig, Neitzel, Carina, Haub, Jessica, Monien, Bernhard H., Nicken, Petra, Steinberg, Pablo, Shay, Jerry W., Kaina, Bernd, Fahrer, Jörg
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137439/
https://ncbi.nlm.nih.gov/pubmed/27599846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw791
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