DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP

PhIP is an abundant heterocyclic aromatic amine (HCA) and important dietary carcinogen. Following metabolic activation, PhIP causes bulky DNA lesions at the C8-position of guanine. Although C8-PhIP-dG adducts are mutagenic, their interference with the DNA replication machinery and the elicited DNA d...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Mimmler, Maximilian, Peter, Simon, Kraus, Alexander, Stroh, Svenja, Nikolova, Teodora, Seiwert, Nina, Hasselwander, Solveig, Neitzel, Carina, Haub, Jessica, Monien, Bernhard H., Nicken, Petra, Steinberg, Pablo, Shay, Jerry W., Kaina, Bernd, Fahrer, Jörg
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2016
Pynciau:
Genome Integrity, Repair and Replication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137439/
https://ncbi.nlm.nih.gov/pubmed/27599846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw791
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