DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP

PhIP is an abundant heterocyclic aromatic amine (HCA) and important dietary carcinogen. Following metabolic activation, PhIP causes bulky DNA lesions at the C8-position of guanine. Although C8-PhIP-dG adducts are mutagenic, their interference with the DNA replication machinery and the elicited DNA d...

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Publicado en:Nucleic Acids Res
Autores principales: Mimmler, Maximilian, Peter, Simon, Kraus, Alexander, Stroh, Svenja, Nikolova, Teodora, Seiwert, Nina, Hasselwander, Solveig, Neitzel, Carina, Haub, Jessica, Monien, Bernhard H., Nicken, Petra, Steinberg, Pablo, Shay, Jerry W., Kaina, Bernd, Fahrer, Jörg
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137439/
https://ncbi.nlm.nih.gov/pubmed/27599846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw791
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