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Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation

Lipoic acid (LA) is a redox-active disulphide compound, which functions as a pivotal co-factor for mitochondrial oxidative decarboxylation. LA and chemical derivatives were shown to target mitochondria in cancer cells with altered energy metabolism, thereby inducing cell death. In this study, the im...

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Dettagli Bibliografici
Pubblicato in:Cells
Autori principali: Neitzel, Carina, Seiwert, Nina, Göder, Anja, Diehl, Erika, Weber, Carina, Nagel, Georg, Stroh, Svenja, Rasenberger, Birgit, Christmann, Markus, Fahrer, Jörg
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721634/
https://ncbi.nlm.nih.gov/pubmed/31366086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8080794
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