PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression

Colorectal cancer (CRC) is one of the most common tumor entities, which is causally linked to DNA repair defects and inflammatory bowel disease (IBD). Here, we studied the role of the DNA repair protein poly(ADP-ribose) polymerase-1 (PARP-1) in CRC. Tissue microarray analysis revealed PARP-1 overexp...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dörsam, Bastian, Seiwert, Nina, Foersch, Sebastian, Stroh, Svenja, Nagel, Georg, Begaliew, Diana, Diehl, Erika, Kraus, Alexander, McKeague, Maureen, Minneker, Vera, Roukos, Vassilis, Reißig, Sonja, Waisman, Ari, Moehler, Markus, Stier, Anna, Mangerich, Aswin, Dantzer, Françoise, Kaina, Bernd, Fahrer, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924876/
https://ncbi.nlm.nih.gov/pubmed/29632181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712345115
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