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Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants

Nowadays, pharmaceutical heparin is purified from porcine and bovine intestinal mucosa. In the past decade there has been an ongoing concern about the safety of heparin, since in 2008, adverse effects associated with the presence of an oversulfated chondroitin sulfate (OSCS) were observed in prepara...

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Vydáno v:Molecules
Hlavní autoři: Mendes, Aline, Meneghetti, Maria C. Z., Palladino, Marcelly Valle, Justo, Giselle Zenker, Sassaki, Guilherme L., Fareed, Jawed, Lima, Marcelo A., Nader, Helena B.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721129/
https://ncbi.nlm.nih.gov/pubmed/31426507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24162988
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