Oversulfated Chondroitin Sulfate is a major contaminant in Heparin associated with Adverse Clinical Events

Heparin has been used clinically as an anticoagulant for over 60 years. Typically isolated from porcine intestine, heparin is a mixture of dimeric glycosidic sequences generating complex polysaccharide glycosaminoglycan chains. Recently, certain lots of heparin have been associated with an acute, ra...

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Autori principali: Guerrini, Marco, Beccati, Dainella, Shriver, Zachary, Naggi, Anna Maria, Bisio, Antonella, Capila, Ishan, Lansing, John, Guglieri, Sara, Fraser, Blair, Al-Hakim, Ali, Gunay, Sibel, Viswanathan, Karthik, Zhang, Zhenqing, Robinson, Luke, Venkataraman, Ganesh, Buhse, Lucinda, Nasr, Moheb, Woodcock, Janet, Langer, Robert, Linhardt, Robert, Casu, Benito, Torri, Giangiacomo, Sasisekharan, Ram
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491566/
https://ncbi.nlm.nih.gov/pubmed/18437154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1407
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