Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1

Sorafenib is a multi-kinase inhibitor and one of the few systemic treatment options for patients with advanced hepatocellular carcinomas (HCCs). Resistance to sorafenib develops frequently and could be mediated by the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin (SIRT)1. We...

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Detaylı Bibliyografya
Yayımlandı:Int J Mol Sci
Asıl Yazarlar: Garten, Antje, Grohmann, Theresa, Kluckova, Katarina, Lavery, Gareth G., Kiess, Wieland, Penke, Melanie
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719220/
https://ncbi.nlm.nih.gov/pubmed/31430957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20164048
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