Hypothalamic mTORC2 is essential for metabolic health and longevity

The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved protein kinase that regulates growth and metabolism. mTOR is found in two protein complexes, mTORC1 and mTORC2, that have distinct components and substrates and are both inhibited by rapamycin, a macrolide drug that robustly e...

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Publicado en:Aging Cell
Main Authors: Chellappa, Karthikeyani, Brinkman, Jacqueline A., Mukherjee, Sarmistha, Morrison, Mark, Alotaibi, Mohammed I., Carbajal, Kathryn A., Alhadeff, Amber L., Perron, Isaac J., Yao, Rebecca, Purdy, Cole S., DeFelice, Denise M., Wakai, Matthew H., Tomasiewicz, Jay, Lin, Amy, Meyer, Emma, Peng, Yajing, Arriola Apelo, Sebastian I., Puglielli, Luigi, Betley, J. Nicholas, Paschos, Georgios K., Baur, Joseph A., Lamming, Dudley W.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718533/
https://ncbi.nlm.nih.gov/pubmed/31373126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13014
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