Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice

DNA methylation is generally known to inactivate gene expression. The DNA methyltransferases (DNMTs), DNMT3A and DNMT3B, catalyze somatic cell lineage‐specific DNA methylation, while DNMT3A and DNMT3L catalyze germ cell lineage‐specific DNA methylation. How such lineage‐ and gene‐specific DNA methyl...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Reprod Dev
Egile Nagusiak: Sasaki, Keisuke, Hara, Satoshi, Yamakami, Reina, Sato, Yusuke, Hasegawa, Saki, Kono, Tomohiro, Morohaku, Kanako, Obata, Yayoi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2019
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718006/
https://ncbi.nlm.nih.gov/pubmed/30834655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrd.23137
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