Overexpression of DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) And DNA (Cytosine-5)-Methyltransferase 3A (DNMT3A) Is Associated with Aggressive Behavior and Hypermethylation of Tumor Suppressor Genes in Human Pituitary Adenomas

BACKGROUND: Alteration of DNA methylation of tumor suppressor genes (TSGs) is one of the most consistent epigenetic changes in human cancers. DNMTs play several important roles in DNA methylation and development of cancers. Regarding DNMTs protein expressions, little is known about the clinical sign...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Med Sci Monit
Autori principali: Ma, Hou-Shi, Wang, Elaine Lu, Xu, Wen-Fei, Yamada, Shozo, Yoshimoto, Katsuhiko, Qian, Zhi Rong, Shi, Long, Liu, Li-Li, Li, Xu-Hui
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Scientific Literature, Inc. 2018
Soggetti:
Lab/In Vitro Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6069575/
https://ncbi.nlm.nih.gov/pubmed/30002361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.910608
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