Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice

DNA methylation is generally known to inactivate gene expression. The DNA methyltransferases (DNMTs), DNMT3A and DNMT3B, catalyze somatic cell lineage‐specific DNA methylation, while DNMT3A and DNMT3L catalyze germ cell lineage‐specific DNA methylation. How such lineage‐ and gene‐specific DNA methyl...

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Dettagli Bibliografici
Pubblicato in:Mol Reprod Dev
Autori principali: Sasaki, Keisuke, Hara, Satoshi, Yamakami, Reina, Sato, Yusuke, Hasegawa, Saki, Kono, Tomohiro, Morohaku, Kanako, Obata, Yayoi
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718006/
https://ncbi.nlm.nih.gov/pubmed/30834655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrd.23137
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