Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice

DNA methylation is generally known to inactivate gene expression. The DNA methyltransferases (DNMTs), DNMT3A and DNMT3B, catalyze somatic cell lineage‐specific DNA methylation, while DNMT3A and DNMT3L catalyze germ cell lineage‐specific DNA methylation. How such lineage‐ and gene‐specific DNA methyl...

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Bibliografische gegevens
Gepubliceerd in:Mol Reprod Dev
Hoofdauteurs: Sasaki, Keisuke, Hara, Satoshi, Yamakami, Reina, Sato, Yusuke, Hasegawa, Saki, Kono, Tomohiro, Morohaku, Kanako, Obata, Yayoi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
Onderwerpen:
Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718006/
https://ncbi.nlm.nih.gov/pubmed/30834655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrd.23137
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